The Buffalo Bills became the fifth team to book a place in the NFL play-offs after clinching their first division title since 1995.
Quarterback Josh Allen threw for two touchdowns and ran for two others as the Bills won 48-19 at the Denver Broncos to move to an 11-3 record.
That clinched the AFC East title with two games of the regular season left.
The New England Patriots, six-time Super Bowl champions, have won the AFC East in 16 of the past 17 years.
Under head coach Sean McDermott, the Bills have now reached the play-offs in three out of four years, having ended their 17-year play-off drought in 2017.