The 2020-21 Nations League draw takes place on Tuesday at 17:00 GMT in Amsterdam, with the home nations waiting to discover their opponents.
There have been several changes from the inaugural 2018-19 event, which Portugal won last summer.
There will now be four teams in each group in the top three divisions - compared to mostly three last time.
It does not offer any guaranteed 2022 World Cup places, whereas the previous version provided four Euro 2020 spots.
Two teams could still qualify for Qatar via this route, though, as two of the 12 World Cup play-off places (for three spots) are available via the Nations League, compared to all 16 play-off teams for the Euros (more on this below).